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Increased activity of the mitochondrial respiratory chain complexes I, II, and III, increases ATP synthesis, resulting in accelerated healing processes. In addition to ATP production triggered by oxygenation, the photons absorbed by the mitochondria results in the release of Nitric Oxide (NO) from photodissociation. Alongside its anti-inflammatory properties, NO acts as a vasodilator which contributes to blood pressure regulation. The implication of NO production in photobiomodulation could protect cardiomyocytes from reoxygenation damage and hypoxia, as well as increase the bioavailability of NO to aid in hypertension.14 Low level laser therapy (LLLT) also has a biostimulational effect on the nervous system through NO production, making it an important mechanism in the modulation of neuropathy/neuralgic pain syndrome.
The increased speed of biochemical reactions and tissue metabolism, as well as moderate vasodilation which increases O2 and nutrient supply and removes catabolites, results in a faster activation of repair processes. Moreover, the decrease of fluid viscosity results in lower rigidity of the tissues and lengthening of connective components, to promote muscle relaxation, which produces a general soothing analgesic effect.
The generation of indirect, non-destructive mechanical effects, promotes the regulation of growth and cell differentiation, protein synthesis, and ECM production, to maintain homeostasis of tissues with structural function (i.e., connective tissue). This regulates the tissue repair processes, further strengthening anti-inflammatory, anti-oedema, and pain relief actions.
To access more research and clinicial studies, please continue to our Literature page.
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